Cross-phenotype association analysis

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August undefined, 2024

WebHis group also developed cross-phenotype association (CPASSOC) that can integrate association evidence from summary statistics of multiple traits, either correlated or independent, continuous or binary, coming from the same or different studies. WebJul 6, 2024 · A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine. Blood pressure (BP) was inconsistently associated with migraine …

An atlas connecting shared genetic architecture of human …

WebThe relationships between HTGW phenotypes and OSA were assessed using binary (apnea hypopnea index, [AHI]≥ 5/hr) and multinomial logistic regression analyses (clinical AHI severity categories). Results: We included 3190 participants in this cross-sectional study. havilah ravula

Discovery and Mediation Analysis of Cross-Phenotype …

WebMethods: Here, we applied disease network analysis and gene-based analysis (GBA) to examine genetic variants linked to GC and simultaneously associated with other … WebMay 17, 2024 · Further investigation of cross-phenotype SNPs associated with both severe COVID-19 and other human traits demonstrated colocalization of the GWAS signal at the ABO locus with plasma protein levels of a reported receptor of SARS-CoV-2, … WebCross-Phenotype Association Analysis Using Summary Statistics from GWAS. For over a decade, genome-wide association studies (GWAS) have been a major tool for detecting genetic variants underlying complex traits. Recent studies have … National Center for Biotechnology Information havilah seguros

Cross-Phenotype Association Analysis Using Summary

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WebGenome-wide association studies (GWAS) for complex diseases have focused primarily on single-trait analyses for disease status and disease-related … WebFeb 15, 2024 · Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury Authors haverkamp yanomamiWebFeb 11, 2024 · 2.3.2 Cross-Phenotype Association Analysis Having identified the significantly genetically related phenotype-pairs, we further conducted cross … havilah you tube

"Web10 rows · Jan 1, 2024 · A CP association can occur in the context of: 1) biological pleiotropy, a SNP or a gene affects multiple phenotypes; 2) phenotype causal relationships, often … " - Cross-phenotype association analysis

Cross-phenotype association analysis

WebJan 4, 2024 · Discovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2 Abstract Twin studies suggest that shared genetics contributes to the comorbidity of asthma and obesity, but candidate-gene studies provide limited evidence of pleiotropy. WebSep 30, 2024 · To expand the atlas of genetic associations, here we conducted 220 deep-phenotype GWASs (that is, 197 electronic medical records (EMR)-based disease and medication records and 23 biomarkers) in...

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WebOct 4, 2016 · Cross-phenotype association analysis (CPASSOC) can further improve statistical power by searching for variants that contribute to multiple traits, which is often … WebApr 7, 2024 · The structure of the maize kernels plays a critical role in determining maize yield and quality, and high-throughput, non-destructive microscope phenotypic …

WebThis study uses genome-wide association studies of depressive symptoms in a longitudinal framework and across. Time-varying phenotypes have been studied less frequently in the context of genome-wide analyses across ethnicities, particularly for mood disorders. This study uses genome-wide association studies of depressive symptoms in a ... WebApr 14, 2024 · These data indicate that one of the major effector mechanisms of microbial therapy is the conversion of tumor neutrophils from a wound healing to an acutely activated cytotoxic phenotype, highlighting a rationale for broader deployment of microbial therapy in the treatment of solid cancers. Significance:

WebFor over a decade, genome-wide association studies (GWAS) have been a major tool for detecting genetic variants underlying complex traits. Recent studies have demonstrated that the same variant or gene can be associated with multiple traits, and such associations are termed cross-phenotype (CP) associations. WebApr 2, 2024 · The resulting marker trait (s) associations are termed cross-phenotype (CP) associations 6. While multivariate approaches 7 allow for direct identification of CP associations, in the context of...

WebWe describe a test of association that can be efficiently applied to large population-based designs. A C++ implementation can be obtained from the authors. UNLABELLED We describe a test of association that can be efficiently applied to large population-based designs. A C++ implementation can be obtained from the authors.

WebOct 4, 2016 · Cross-phenotype association … Meta-analysis of single trait for multiple cohorts has been used for increasing statistical power in genome-wide association … haveri karnataka 581110WebAug 11, 2024 · Cross-phenotype associations may also arise due to issues related to study design, confounder bias, or nongenetic causal links between the phenotypes under … haveri to harapanahalliWebOct 23, 2024 · This review also discusses the challenges of identifying interactions between genetic mutations (epistasis) and mutations of loci affecting more than one trait … haveriplats bermudatriangelnWebApr 13, 2024 · The aim of cross-sectional study was to investigate whether the presence of autistic traits in pregnant women was positively associated with the prevalence and severity of antenatal pain. We... havilah residencialWebJun 11, 2013 · The cross-phenotype meta-analysis (CPMA) statistic 14 also uses association P values and tests whether the observed P values deviate from the expected distribution of P values under the null ... havilah hawkinsWebFeb 9, 2024 · Its key features include: 1) comprehensive collection and deep annotation of SNP-metabolite associations based on data from the 65 mGWAS to date; 2) supporting SNP-based, gene-based, metabolite … haverkamp bau halternWebAsymptomatic Hyperuricemia and Metabolically Unhealthy Obesity: A Cross-Sectional Analysis in the Tianning Cohort . Fulltext; Metrics; Get Permission; Cite this article; Authors Yu J , Sun H, Zhu J, Wei X, Shi H, Shen B, Ren L, He Y, Zhang R, Zhang M , Peng H . Received 14 January 2024. have you had dinner yet meaning in punjabi