Cullin_2 domain-containing protein
WebJul 20, 2012 · One of seven cullin proteins serves as a scaffold protein for the assembly of the multisubunit ubiquitin ligase complex. Cullin binds the RING domain protein … WebAug 5, 2024 · CULLIN_2 domain-containing protein;Cullin-3;Cullin_Nedd8 domain-containing protein GeneRIFs: Gene References Into Functions KEL-8 is a substrate …
Cullin_2 domain-containing protein
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WebMar 29, 2024 · Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer Twist1 bound the Cul2 promoter. direct evidence that both A3A and HPV16 E7 interact with CUL2, … WebApr 16, 2024 · The BTB domain, also known as POZ (poxvirus and zinc finger) domain, is a protein-protein interaction motif in eukaryotes [ 12]. All eukaryotes have a large variety of proteins that contain a BTB/POZ domain.
WebSkp, Cullin, F-box containing complex (or SCF complex) is a multi-protein E3 ubiquitin ligase complex that catalyzes the ubiquitination of proteins destined for 26S proteasomal degradation. [1] Along with the anaphase-promoting complex, [2] SCF has important roles in the ubiquitination of proteins involved in the cell cycle. WebBy examining genes arising from intra- and interchromosomal duplications involving the ancestral chromosome 2 fusion site, followed by PCR of a fetal brain cDNA library, Fan …
WebHerein, we describe the protein-l-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1) as a putative E3 ubiquitin ligase substrate adaptor protein. ... However, this protein is able to associate with the Cullin-RING proteins Elongins B and C and Cul5 in vitro and in human cells. The previously uncharacterized PCMTD1 protein … WebOct 21, 2013 · The tumor suppressor VHL (von Hippel–Lindau) protein is a substrate receptor for Ubiquitin Cullin Ring Ligase complexes (CRLs), containing a BC-box domain that associates to the adaptor Elongin B/C. VHL targets hypoxia-inducible factor 1α to proteasome-dependent degradation. Gam1 is an adenoviral protein, which also …
WebOct 9, 2024 · 9-Oct-2024 Summary Contributes to ubiquitin-protein transferase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2024]
WebApr 5, 2024 · 无齿E3泛素蛋白连接酶同源物(denticleless E3 ubiquitin protein ligase homolog,DTL)作为E3泛素连接酶中重要的底物适配器,是促进细胞周期进程和基因组稳定性的中心调控因子。 ... [2]。Cullin-RING E3泛素连接酶(Cullin-RING E3 ligase,CRL)拥有庞大的家族,参与基因转录 ... danish cot bedWebMar 21, 2024 · DCUN1D1 (Defective In Cullin Neddylation 1 Domain Containing 1) is a Protein Coding gene. Diseases associated with DCUN1D1 include Squamous Cell Carcinoma and Scrotum Squamous Cell Carcinoma . Among its related pathways are Metabolism of proteins and protein neddylation . An important paralog of this gene is … birthday cake neon abyssWebThe remaining 38 BTB-domain containing proteins were slightly more abundant in CUL3-∆9 (≥2-fold ... Cullin-Ring Ligases (CRL) are multi-subunit E3 ubiquitin ligases nucleated around a cullin scaffold protein controlling the ubiquitin-mediated proteasomal degradation of a large number of protein substrates. Cullin 3 (CUL3), as all cullin ... danish couchWebOct 2, 2024 · To date, at least 70 F-box protein receptors have been identified for CRL1, a handful of VHL domain-containing proteins for CRL2: approximately 180 BTB proteins … birthday cake music themeWebNov 5, 2013 · Abstract The tumor suppressor VHL (von Hippel-Lindau) protein is a substrate receptor for Ubiquitin Cullin Ring Ligase complexes (CRLs), containing a BC-box domain that associates to the adaptor Elongin B/C. VHL targets hypoxia-inducible factor 1α to proteasome-dependent degradation. birthday cake name picturesWebUbiquitin-conjugating Enzyme E2M (UBE2M), also known as Ubiquitin-conjugating Enzyme 12 (Ubc12), is a ubiquitously expressed protein with a predicted molecular weight of 20 kDa. UBE2M/Ubc12 is highly conserved, and the human ortholog shares 100% amino acid identity with mouse and rat UBE2M. UBE2M/Ubc12 mediates conjugation of the … birthday cake muffin recipeWebCullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of … birthday cake near me online