Incb10820
WebMar 1, 2011 · Bioorg Med Chem Lett 2011 Mar 11;21(5):1442-6. Epub 2011 Jan 11. Incyte Corporation, Experimental Station E336, Wilmington, DE 19880, USA. WebINCB10820. INCB10820 (PF-4178903) is a potent, selective, orally bioavailable dual CCR2 and CCR5 antagonist with binding IC50 of 3.0 nM and 5.3 nM, respectively.
Incb10820
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WebDiscovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist Overview of attention for article published in Bioorganic & Medicinal … WebDiscovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist,Bioorganic & Medicinal Chemistry Letters,Chu-Biao Xue,ccr2, antagonist, chemokine, ccr5
WebChemokine Receptor compound (inhibitors, antagonists, agonists) with high quality and purity, chemical tool in various assays for drug discovery and biological research, potent, subtype selective CCR and CXCR small molecule inhibitor. WebVirtual screening (VS) has become an integral part of the drug discovery process and is a valuable tool for finding novel chemical starting points for GPCR targets. ...
WebDec 20, 2024 · In this study we investigate the orthosteric antagonist MK-0812, a tetrahydropyranyl cyclopentyl tetrahydropyridopyridine derivative discovered by Merck as a dual CCR2/CCR5 antagonist ( Struthers and Pasternak, 2010 ). This compound showed in vivo activity by preventing the infiltration of macrophages in mouse models ( Wisniewski … WebMar 1, 2011 · Incyte and Pfizer recently described the identification of INCB-10820/PF-4178903, from a collaboration established in 2005 to identify CCR2 antagonists, and its …
WebZheng C, Cao G, Xia M, et al. (2011) Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist. Bioorganic & Medicinal Chemistry Letters . 21: 1442-6
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